Multiple Expressed Endogenous Glioma Epitopes as Novel Vaccines for Gliomas

Pedro R Lowenstein; Maria G Castro

doi:10.1158/1078-0432.CCR-16-1477

Multiple Expressed Endogenous Glioma Epitopes as Novel Vaccines for Gliomas

Clin Cancer Res. 2016 Oct 1;22(19):4760-4762. doi: 10.1158/1078-0432.CCR-16-1477. Epub 2016 Aug 12.

Authors

Pedro R Lowenstein¹, Maria G Castro²

Affiliations

¹ Department of Neurosurgery, The Cancer Biology and The Immunology Graduate Programs, The Cancer Center, The University of Michigan School of Medicine, Ann Arbor, Michigan. Department of Cell and Developmental Biology, The University of Michigan School of Medicine, Ann Arbor, Michigan. pedrol@umich.edu.
² Department of Neurosurgery, The Cancer Biology and The Immunology Graduate Programs, The Cancer Center, The University of Michigan School of Medicine, Ann Arbor, Michigan. Department of Cell and Developmental Biology, The University of Michigan School of Medicine, Ann Arbor, Michigan.

Abstract

A novel approach to immunization against glioma tumors is described. Immunization against 11 antigens expressed in malignant brain tumors elicits responses to one or more antigens in a large percentage of patients. This novel approach suggests that it could be extended to a phase III trial. Clin Cancer Res; 22(19); 4760-2. ©2016 AACRSee related article by Rampling et al., p. 4776.

Publication types

Comment

MeSH terms

Adult
Antigens, Neoplasm
Brain Neoplasms*
Cancer Vaccines*
Epitopes
Glioblastoma*
Glioma*
Humans
Peptides
United Kingdom

Substances

Antigens, Neoplasm
Cancer Vaccines
Epitopes
IMA950
Peptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding