Interpenetrating hydrogels of O-carboxymethyl Tamarind gum and alginate for monitoring delivery of acyclovir

Abstract

In this work, an interpenetrating hydrogel network was constructed using varying combination of O-carboxymethyl Tamarind gum (CTG) and alginate by Ca⁺² ion induced gelation method. The hydrogels were characterized by FTIR spectroscopy, Field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and differential scanning calorimetry (DSC) analyses. The hydrogels were spherical in shape with rough surface textures. Depending on the alginate: CTG mass ratio, the hydrogel particles entrapped a maximum of ∼70% acyclovir. The drug release from interpenetrating hydrogels was 18-23% in HCl solution (pH1.2) in 2h. The drug release became faster in phosphate buffer solution (pH6.8) as the proportion of CTG was increased from 25% to 50%. However, the drug release was still slower than that observed for hydrogel particles of sodium alginate alone. Overall, the drug release tendency of the particles was higher in phosphate buffer solution than that in HCl solution. The non-Fickian drug release behavior was assumed after fitting the drug release data into Korsmeyer-Peppas model. The drug release was found to control by diffusion and swelling kinetics of the hydrogels. Thus, CTG gum could effectively retard drug release when used in combination with sodium alginate at an optimized mass ratio.

Keywords: Acyclovir; Controlled release; Hydrogels; Interpenetrating network; O-Carboxymethyl Tamarind gum; Sodium alginate.