Immunotherapeutic strategies for sexually transmitted viral infections: HIV, HSV and HPV

Cell Immunol. 2016 Dec:310:1-13. doi: 10.1016/j.cellimm.2016.08.001. Epub 2016 Aug 3.

Abstract

More than 1 million sexually transmitted infections (STIs) are acquired each day globally. Etiotropic drugs cannot effectively control infectious diseases therefore, there is a dire need to explore alternative strategies especially those based on the regulation of immune system. The review discusses all rational approaches to develop better understanding towards immunotherapeutic strategies based on modulation of immune system in an attempt to curb the elevating risk of infectious diseases such as HIV, HPV and HSV because of their high prevalence. Development of monoclonal antibodies, vaccines and several other immune based treatments are promising alternative strategies that are offering new opportunities to eradicate pathogens.

Keywords: HIV; HPV; HSV; Immune system; Immunotherapeutic; Strategies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • HIV Infections / immunology
  • HIV Infections / therapy*
  • Herpes Simplex / immunology
  • Herpes Simplex / therapy*
  • Humans
  • Immunomodulation
  • Immunotherapy / methods*
  • Immunotherapy / trends
  • Papillomavirus Infections / immunology
  • Papillomavirus Infections / therapy*
  • Sexually Transmitted Diseases, Viral / immunology
  • Sexually Transmitted Diseases, Viral / therapy*
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Monoclonal
  • Viral Vaccines