Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation

Phytochemistry. 2016 Oct:130:335-42. doi: 10.1016/j.phytochem.2016.08.001. Epub 2016 Aug 6.

Abstract

Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.

Keywords: Eudesmane sesquiterpenoids; IL-6; Inflammation; Lamiaceae; STAT3; Salvia plebeia.

MeSH terms

  • Crystallography, X-Ray
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Inhibitory Concentration 50
  • Interleukin-6 / pharmacology*
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Components, Aerial / chemistry
  • STAT3 Transcription Factor / drug effects*
  • Salvia / chemistry*
  • Sesquiterpenes, Eudesmane / chemistry
  • Sesquiterpenes, Eudesmane / isolation & purification*
  • Sesquiterpenes, Eudesmane / pharmacology*

Substances

  • Drugs, Chinese Herbal
  • Interleukin-6
  • Lactones
  • STAT3 Transcription Factor
  • Sesquiterpenes, Eudesmane
  • eudebeiolide D