Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae

Pranita D Tamma; Yanjie Huang; Belita N A Opene; Patricia J Simner

doi:10.1128/AAC.00838-16

Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6425-9. doi: 10.1128/AAC.00838-16. Print 2016 Oct.

Authors

Pranita D Tamma¹, Yanjie Huang², Belita N A Opene³, Patricia J Simner³

Affiliations

¹ Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ptamma1@jhmi.edu.
² Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
³ Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 μg/ml and meropenem, imipenem, and doripenem MICs of 2 μg/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / metabolism*
Carbapenems / pharmacology*
Drug Resistance, Bacterial / drug effects
Enterobacteriaceae / drug effects*
Enterobacteriaceae / isolation & purification
Enterobacteriaceae / metabolism
Humans
Microbial Sensitivity Tests / methods*
ROC Curve
beta-Lactamases / metabolism*

Substances

Bacterial Proteins
Carbapenems
beta-Lactamases
carbapenemase