The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes

S Rastegar; U Strähle

doi:10.1016/bs.adgen.2016.04.003

The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes

Adv Genet. 2016:95:195-216. doi: 10.1016/bs.adgen.2016.04.003. Epub 2016 Jun 13.

Authors

S Rastegar¹, U Strähle²

Affiliations

¹ Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
² Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany; Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.

PMID: 27503358
DOI: 10.1016/bs.adgen.2016.04.003

Abstract

Despite enormous progress to map cis-regulatory modules (CRMs), like enhancers and promoters in genomes, elucidation of the regulatory landscape of the developing embryo remains a challenge. The zebrafish embryo with its experimental virtues has a great potential to contribute to this endeavor. However, so far progress remained behind expectation. We discuss here available methods and their limitations and how the zebrafish embryo could contribute in the future to unravel the wiring of the vertebrate genome.

Keywords: Enhancer; Epigenetics; Genetics; Transcription regulation; Zebrafish; cis-Regulatory modules.

Publication types

Review

MeSH terms

Animals
Gene Expression Regulation, Developmental / genetics*
Genome / genetics*
Humans
Regulatory Sequences, Nucleic Acid / genetics
Transcription, Genetic / genetics
Zebrafish / genetics*