MicroRNAs as key mediators of hepatic detoxification

Yemiao Chen; Jingfang Xiao; Xinli Zhang; Xiuwu Bian

doi:10.1016/j.tox.2016.08.005

MicroRNAs as key mediators of hepatic detoxification

Toxicology. 2016 Aug 10:368-369:80-90. doi: 10.1016/j.tox.2016.08.005. Epub 2016 Aug 5.

Authors

Yemiao Chen¹, Jingfang Xiao², Xinli Zhang², Xiuwu Bian³

Affiliations

¹ Institute of Pathology and Southwest Cancer Center, Southwest Hospital and Key Laboratory of Tumor Immunopathology of the Ministry of Education of China, Third Military Medical University, China. Electronic address: chenyemiao@tmmu.edu.cn.
² Institute of Pathology and Southwest Cancer Center, Southwest Hospital and Key Laboratory of Tumor Immunopathology of the Ministry of Education of China, Third Military Medical University, China.
³ Institute of Pathology and Southwest Cancer Center, Southwest Hospital and Key Laboratory of Tumor Immunopathology of the Ministry of Education of China, Third Military Medical University, China. Electronic address: bianxiuwu@263.net.

PMID: 27501766
DOI: 10.1016/j.tox.2016.08.005

Abstract

MicroRNAs (miRNAs) are a class of short noncoding RNAs that modulate gene expression at both transcriptional and post-transcriptional levels. Many studies have extensively revealed the significance of miRNAs in mediating liver development and diseases. However, their role in hepatic detoxification processes has been explored only recently. In this review, we summarized the up-to-date knowledge about miRNA dependent regulation of enzymes involved in all three phases of the drugs and xenobiotics detoxification process. We also discussed the role of miRNA in regulating some upstream nuclear receptors involving gene expression of enzymes for detoxification process in liver. The toxicological significance of miRNAs in liver diseases and future research perspectives are finally presented.

Keywords: Hepatic detoxification; MicroRNA; Phase I enzymes; Phase II enzymes; Phase III enzymes.

Publication types

Review

MeSH terms

Amino Acid Transport Systems, Neutral / genetics*
Amino Acid Transport Systems, Neutral / metabolism
Animals
Cell Line, Tumor
Cytochrome P-450 Enzyme System / genetics*
Cytochrome P-450 Enzyme System / metabolism
Disease Models, Animal
Female
Gene Expression Regulation, Enzymologic*
Humans
Inactivation, Metabolic / genetics
Liver / drug effects*
Liver / metabolism
Liver Diseases / drug therapy
Liver Diseases / genetics
Male
MicroRNAs / genetics*
MicroRNAs / metabolism
Organogenesis / drug effects
Organogenesis / genetics
Receptors, Cytoplasmic and Nuclear / metabolism
Xenobiotics / pharmacokinetics*

Substances

Amino Acid Transport Systems, Neutral
MicroRNAs
Receptors, Cytoplasmic and Nuclear
Xenobiotics
Cytochrome P-450 Enzyme System