Toward a theory of organisms: Three founding principles in search of a useful integration

Prog Biophys Mol Biol. 2016 Oct;122(1):77-82. doi: 10.1016/j.pbiomolbio.2016.07.006. Epub 2016 Aug 4.

Abstract

Organisms, be they uni- or multi-cellular, are agents capable of creating their own norms; they are continuously harmonizing their ability to create novelty and stability, that is, they combine plasticity with robustness. Here we articulate the three principles for a theory of organisms, namely: the default state of proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly change both biological observables and their determination with respect to the theoretical framework of physical theories. This radical change opens up the possibility of anchoring mathematical modeling in biologically proper principles.

Keywords: Biological organization; Default state; Individuation; Organizational closure; Variation.

Publication types

  • Review

MeSH terms

  • Animals
  • Models, Biological*