The importance of surfactant proteins-New aspects on macrophage phagocytosis

Thomas Tschernig; Nils T Veith; Ebru Diler; Markus Bischoff; Carola Meier; Martin Schicht

doi:10.1016/j.aanat.2016.07.005

The importance of surfactant proteins-New aspects on macrophage phagocytosis

Ann Anat. 2016 Nov:208:142-145. doi: 10.1016/j.aanat.2016.07.005. Epub 2016 Aug 3.

Authors

Thomas Tschernig¹, Nils T Veith², Ebru Diler³, Markus Bischoff⁴, Carola Meier³, Martin Schicht⁵

Affiliations

¹ Department of Anatomy and Cell Biology, Saarland University, Homburg, Saar, Germany. Electronic address: thomas.tschernig@uks.eu.
² Department of Traumatology, Saarland University, Homburg, Saar, Germany.
³ Department of Anatomy and Cell Biology, Saarland University, Homburg, Saar, Germany.
⁴ Department of Medical Microbiology and Hygiene, Saarland University, Homburg, Saar, Germany.
⁵ Department of Anatomy II, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.

PMID: 27498043
DOI: 10.1016/j.aanat.2016.07.005

Abstract

Surfactant and its components have multiple functions. The so called collectins are surfactant proteins which opsonize bacteria and improve pulmonary host defense via the phagocytosis and clearance of microorganisms and particles. In this special issue of the Annals of Anatomy a new surfactant protein, Surfactant Associated 3, is highlighted. As outlined in this mini review Surfactant Associated 3 is regarded as an enhancer of phagocytosis. In addition, the role played by SP-A is updated and open research questions raised.

Keywords: Host defense; Phagocytosis; SFTA3; Staphylococci; Surfactant; Surfactant Associated 3; Surfactant proteins.

Publication types

Review

MeSH terms

Humans
Immunity, Innate / immunology*
Lung / immunology*
Macrophages / immunology*
Models, Immunological*
Phagocytosis / immunology*
Pulmonary Surfactant-Associated Proteins / immunology*

Substances

Pulmonary Surfactant-Associated Proteins
SFTA3 protein, human