Expression of Cytokine Genes and Growth Factors in Rat Lungs and Kidneys after Subtotal Hepatectomy

A V Elchaninov; T Kh Fatkhudinov; N Yu Usman; I V Arutyunyan; A V Makarov; E Yu Kananykhina; V V Glinkina; G B Bolshakova; G T Sukhikh

doi:10.1007/s10517-016-3423-1

Expression of Cytokine Genes and Growth Factors in Rat Lungs and Kidneys after Subtotal Hepatectomy

Bull Exp Biol Med. 2016 Jul;161(3):395-9. doi: 10.1007/s10517-016-3423-1. Epub 2016 Aug 6.

Authors

A V Elchaninov¹, T Kh Fatkhudinov², N Yu Usman¹, I V Arutyunyan¹, A V Makarov¹, E Yu Kananykhina^{1

3}, V V Glinkina⁴, G B Bolshakova³, G T Sukhikh¹

Affiliations

¹ V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
² V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.
³ State Research Institute of Human Morphology, Moscow, Russia.
⁴ N. I. Pirogov National Research Medical University, Moscow, Russia.

PMID: 27496032
DOI: 10.1007/s10517-016-3423-1

Abstract

Expression of il1b, il6, il10, tnfa, hgf, tgfb, vegf, and fgf2 genes in the lungs and kidneys was examined on rat model of liver regeneration after subtotal hepatectomy. Enhanced expression of il6, il10, tnfa, hgf, and fgf2 genes was detected at the early terms after 80% liver resection.

Keywords: kidneys; liver; lungs; regeneration; subtotal hepatectomy.

MeSH terms

Animals
Hepatectomy
Hepatocyte Growth Factor / metabolism
Interleukin-10 / metabolism
Interleukin-6 / metabolism
Kidney / metabolism*
Liver Regeneration / physiology
Lung / metabolism*
Rats
Rats, Sprague-Dawley
Transforming Growth Factor beta / metabolism
Tumor Necrosis Factor-alpha / metabolism
Vascular Endothelial Growth Factor A / metabolism

Substances

Interleukin-6
Transforming Growth Factor beta
Tumor Necrosis Factor-alpha
Vascular Endothelial Growth Factor A
Interleukin-10
Hepatocyte Growth Factor