Transient Hyperphosphatasemia (TH) is a benign condition in which serum alkaline phosphatase (ALP) is transiently elevated in the absence of other systemic diseases. It mainly occurs in infants and children and very rarely seen in adults. The differential diagnosis may include liver, bone, kidney, intestinal, placental and blood diseases as well as other serious conditions as well as bone fracture due to accidental or non-accidental injuries. In this report, we present tow of our patients with TH and compare their clinical course with the natural history of TH described in literature. We also provide a focused review, in relevance to our presented cases, of this disease, which is rarely encountered in clinical practice.
Keywords: Alkaline phosphatase; Hyperphosphatasemia; Saudi Arabia; Transient; hyperphosphatasia.