Characteristic calcaneal ossification: an additional early radiographic finding in infants with fibrodysplasia ossificans progressiva

Pediatr Radiol. 2016 Oct;46(11):1568-72. doi: 10.1007/s00247-016-3662-3. Epub 2016 Aug 4.

Abstract

Background: We have clinically encountered children with fibrodysplasia ossificans progressiva who had abnormal calcaneal ossification.

Objective: To evaluate whether calcaneal ossification variants are significant radiographic findings in children with fibrodysplasia ossificans progressiva.

Materials and methods: Lateral feet radiographs in nine children who fulfilled the diagnostic criteria of fibrodysplasia ossificans progressiva were reviewed. The studies were obtained during infancy or early childhood.

Results: Fourteen lateral foot radiographs of fibrodysplasia ossificans progressiva were available for this study (ages at examination: 1-104 months). Four children ages 2 months to 11 months showed double calcaneal ossification centers; 7 children had plantar calcaneal spurs that decreased in size with age. Overall, eight of nine children with fibrodysplasia ossificans progressiva demonstrated double calcaneal ossifications and/or plantar calcaneal spurs in infancy or childhood.

Conclusion: Double calcaneal ossification centers in early infancy and plantar calcaneal spurs in childhood are frequently seen in children with fibrodysplasia ossificans progressiva and may be a useful radiologic indicator for early diagnosis.

Keywords: Calcaneal spur; Children; Double calcaneal ossification center; Early diagnosis; Fibrodysplasia ossificans progressiva; Radiography.

MeSH terms

  • Calcaneus / diagnostic imaging*
  • Calcaneus / pathology*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Myositis Ossificans / diagnostic imaging*
  • Myositis Ossificans / pathology*