Response to comment on "Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice"

Sci Transl Med. 2016 Aug 3;8(350):350lr2. doi: 10.1126/scitranslmed.aag2816.

Abstract

Low-dose resveratrol did not have the opposite effect on intestinal adenoma development when given in a standard diet instead of a high-fat diet, although we agree on the need for more information on the interaction of diet-derived compounds such as resveratrol and other lifestyle, metabolic and hormonal factors.

Publication types

  • Letter
  • Comment

MeSH terms

  • Adenoma / drug therapy
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use
  • Carcinogenesis / drug effects
  • Chemoprevention / methods*
  • Colorectal Neoplasms / drug therapy
  • Diet, High-Fat / adverse effects
  • Female
  • Humans
  • Male
  • Mice
  • Resveratrol
  • Stilbenes / administration & dosage
  • Stilbenes / therapeutic use*

Substances

  • Antioxidants
  • Stilbenes
  • Resveratrol