Two new sesquiterpenoids produced by halophilic Nocardiopsis chromatogenes YIM 90109

Nat Prod Res. 2017 Jan;31(1):77-83. doi: 10.1080/14786419.2016.1214831. Epub 2016 Aug 2.

Abstract

Two new germacradiene-type sesquiterpenoids, including 1(10)E,5E-germacradiene-9β,11-diol (or 9β-hydroxyl germacradienol) (1) and 11-hydroxy-1(10)E,5E-germacradien-2-one (2-oxygermacradienol) (2), together with a known geosmin-type sesquiterpenoid (1β,4β,4aβ,7α,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a,7(2H)-triol (3), were elucidated by their NMR spectroscopic data, HR-ESI-MS and single-crystal X-ray diffraction from the halophilic strain Nocardiopsis chromatogenes YIM 90109. The antimicrobial activities were evaluated by paper diffusion method.

Keywords: Germacradiene-type sesquiterpenoids; Nocardiopsis chromatogenes; antimicrobial activities; crystal X-ray diffraction.

MeSH terms

  • Actinomycetales / chemistry*
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects
  • Fermentation
  • Fungi / drug effects
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology*
  • Spectrometry, Mass, Electrospray Ionization
  • X-Ray Diffraction

Substances

  • (10)E,5E-germacradiene-9beta,11-diol
  • 11-hydroxy-1(10)E,5E-germacradien-2-one
  • Anti-Infective Agents
  • Sesquiterpenes