How Quorum Sensing Connects Sporulation to Necrotrophism in Bacillus thuringiensis

PLoS Pathog. 2016 Aug 2;12(8):e1005779. doi: 10.1371/journal.ppat.1005779. eCollection 2016 Aug.

Abstract

Bacteria use quorum sensing to coordinate adaptation properties, cell fate or commitment to sporulation. The infectious cycle of Bacillus thuringiensis in the insect host is a powerful model to investigate the role of quorum sensing in natural conditions. It is tuned by communication systems regulators belonging to the RNPP family and directly regulated by re-internalized signaling peptides. One such RNPP regulator, NprR, acts in the presence of its cognate signaling peptide NprX as a transcription factor, regulating a set of genes involved in the survival of these bacteria in the insect cadaver. Here, we demonstrate that, in the absence of NprX and independently of its transcriptional activator function, NprR negatively controls sporulation. NprR inhibits expression of Spo0A-regulated genes by preventing the KinA-dependent phosphorylation of the phosphotransferase Spo0F, thus delaying initiation of the sporulation process. This NprR function displays striking similarities with the Rap proteins, which also belong to the RNPP family, but are devoid of DNA-binding domain and indirectly control gene expression via protein-protein interactions in Bacilli. Conservation of the Rap residues directly interacting with Spo0F further suggests a common inhibition of the sporulation phosphorelay. The crystal structure of apo NprR confirms that NprR displays a highly flexible Rap-like structure. We propose a molecular regulatory mechanism in which key residues of the bifunctional regulator NprR are directly and alternatively involved in its two functions. NprX binding switches NprR from a dimeric inhibitor of sporulation to a tetrameric transcriptional activator involved in the necrotrophic lifestyle of B. thuringiensis. NprR thus tightly coordinates sporulation and necrotrophism, ensuring survival and dissemination of the bacteria during host infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus thuringiensis / physiology*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Crystallography, X-Ray
  • Gene Expression Regulation, Bacterial / physiology*
  • Host-Parasite Interactions / physiology*
  • Life Cycle Stages / physiology*
  • Models, Molecular
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Quorum Sensing / physiology*
  • Spores, Bacterial / metabolism

Substances

  • Bacterial Proteins

Grants and funding

This work was supported in part by Université Paris-Sud, the Centre National de la Recherche Scientifique (CNRS, http://www.cnrs.fr/en), the Institut National de la Recherche Agronomique (INRA, http://www.jouy.inra.fr/en) and the grant Cell.com number NT09_443605 from the Agence Nationale de la Recherche (ANR, http://www.agence-nationale-recherche.fr/en/project-based-funding-to-advance-french-research/) as well as the French Infrastructure for Integrated Structural Biology (FRISBI). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.