This work presents and describes a 20-year long database of GPS data collected by geodetic surveys over the seismically and volcanically active eastern Sicily, for a total of more than 6300 measurements. Raw data were initially collected from the various archives at the Istituto Nazionale di Geofisica e Vulcanologia, Sezione di Catania-Osservatorio Etneo and organized in a single repository. Here, quality and completeness checks were performed, while all necessary supplementary information were searched, collected, validated and organized together with the relevant data. Once all data and information collections were completed, raw binary data were converted into the universal ASCII RINEX format; all data are provided in this format with the necessary information for precise processing. In order to make the data archive readily consultable, we developed software allowing the user to easily search and obtain the needed data by simple alphanumeric and geographic queries.