Multi-functional lectin-like transcript-1: A new player in human immune regulation

Immunol Lett. 2016 Sep:177:62-9. doi: 10.1016/j.imlet.2016.07.007. Epub 2016 Jul 28.

Abstract

Lectins and C-type lectins are a heterogeneous group of proteins with a diverse range of functions. Two C-type lectins, found in the Natural Killer gene Complex (NKC), Lectin-like transcript 1 (LLT1) and CD161, have recently gained interest from a broad range of immunological and non-immunological fields. LLT1 in particular has a diverse functional repertoire, from NK cell and B cell regulation to bone metabolism. This review seeks to bring together nearly two decades of research on these receptors and describe their importance in the immune system.

Keywords: C-type lectin-like receptors; Carbohydrate recognition domain; Lectin-like transcript 1; Natural killer gene complex; Osteoclast inhibitory lectin.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • Bone and Bones / metabolism*
  • Humans
  • Immunity
  • Immunomodulation
  • Killer Cells, Natural / immunology*
  • Lectins, C-Type / immunology*
  • NK Cell Lectin-Like Receptor Subfamily B / immunology*
  • Osteogenesis
  • Receptors, Cell Surface / immunology*

Substances

  • CLEC2D protein, human
  • KLRB1 protein, human
  • Lectins, C-Type
  • NK Cell Lectin-Like Receptor Subfamily B
  • Receptors, Cell Surface