Should I Stay or Should I Go?

Wim Vanduffel; John T Arsenault

doi:10.1016/j.neuron.2016.07.012

Should I Stay or Should I Go?

Neuron. 2016 Jul 20;91(2):207-10. doi: 10.1016/j.neuron.2016.07.012.

Authors

Wim Vanduffel¹, John T Arsenault²

Affiliations

¹ Laboratory of Neuro-and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000 Leuven, Belgium; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA 02114, USA. Electronic address: wim@nmr.mgh.harvard.edu.
² Laboratory of Neuro-and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000 Leuven, Belgium; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.

PMID: 27477011
DOI: 10.1016/j.neuron.2016.07.012

Abstract

In this issue of Neuron, Lee et al. (2016) assessed the brain-wide effects of stimulating the direct and indirect pathway by optogenetic activation of D1 and D2 striatal neurons. This work demonstrates the exquisite power of combining cell-type-specific perturbation methods with focal and whole-brain measurements of brain activity.

Publication types

Review
Comment

MeSH terms

Animals
Corpus Striatum / drug effects*
Corpus Striatum / metabolism
Dopamine / metabolism*
Dopamine Antagonists / pharmacology*
Humans
Neurons / drug effects*
Neurons / physiology
Receptors, Dopamine D1 / metabolism*
Receptors, Dopamine D2 / metabolism*

Substances

Dopamine Antagonists
Receptors, Dopamine D1
Receptors, Dopamine D2
Dopamine