Effects of serine proteinase from Staphylococcus aureus V8 cells on Con A stimulation of human lymphocytes

Z Porwit-Bobr; T Ochalek; L Prokesova; C John; K Baran; J Potempa

Effects of serine proteinase from Staphylococcus aureus V8 cells on Con A stimulation of human lymphocytes

Microbiologica. 1989 Apr;12(2):139-42.

Authors

Z Porwit-Bobr¹, T Ochalek, L Prokesova, C John, K Baran, J Potempa

Affiliation

¹ Department of Microbiology and Immunology, Jan Zurzycki Institute of Molecular Biology, Jagiellonian University, Krakow, Czechoslovakia.

PMID: 2747551

Abstract

The combined effect of serum and Staphylococcus aureus serine proteinase on human lymphocyte Con A stimulation was assayed. Serum was found to protect the proteinase-treated lymphocytes. It is suggested that not only the immunogenicity of proteinase itself, but also proteinase modified serum and lymphocyte-derived components affect lymphoproliferative response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Concanavalin A / pharmacology*
Humans
Lymphocyte Activation / drug effects*
Lymphocytes / drug effects*
Lymphocytes / immunology
Serine Endopeptidases / immunology
Serine Endopeptidases / pharmacology*
Staphylococcus aureus / enzymology*
Staphylococcus aureus / immunology

Substances

Concanavalin A
Serine Endopeptidases