A rapid decline in corneal small fibers and occurrence of foot ulceration and Charcot foot

Abstract

We present clinical, neuropathy and corneal nerve morphology data in a participant with type 2 diabetes who developed diabetic foot ulceration, partial amputation and Charcot during a longitudinal observational study. While conventional measures of neuropathy did not deteriorate significantly, corneal nerve parameters showed a rapid reduction prior to the development of foot complications.

Keywords: Corneal confocal microscopy; Corneal nerve morphology; Diabetic foot complications; Diabetic peripheral neuropathy; Neuropathy measures.