pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery

Dawei Hua; Zhongche Liu; Fang Wang; Buhong Gao; Fei Chen; Qilu Zhang; Ranhua Xiong; Jingquan Han; Sangram Keshari Samal; Stefaan C De Smedt; Chaobo Huang

doi:10.1016/j.carbpol.2016.06.066

pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery

Carbohydr Polym. 2016 Oct 20:151:1240-1244. doi: 10.1016/j.carbpol.2016.06.066. Epub 2016 Jun 17.

Authors

Dawei Hua¹, Zhongche Liu¹, Fang Wang¹, Buhong Gao², Fei Chen³, Qilu Zhang⁴, Ranhua Xiong⁵, Jingquan Han⁶, Sangram Keshari Samal⁷, Stefaan C De Smedt⁸, Chaobo Huang⁹

Affiliations

¹ College of Chemical Engineering, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University (NFU), Nanjing 210037 PR China.
² Advanced Analysis & Testing Center, Nanjing Forestry University, Nanjing 210037, PR China.
³ Department of Chemical Engineering, Queen's University, Kingston, Ontario K7 L 3N6, Canada.
⁴ Laboratory of Polymer Chemistry, Department of Chemistry, P.O. Box 55, 00014 University of Helsinki, Finland.
⁵ Lab General Biochemistry & Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium.
⁶ College of Materials Science and Engineering, Nanjing Forestry University (NFU), Nanjing 210037 PR China.
⁷ Lab General Biochemistry & Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium. Electronic address: SangramKeshari.Samal@UGent.be.
⁸ Lab General Biochemistry & Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium. Electronic address: Stefaan.Desmedt@UGent.be.
⁹ College of Chemical Engineering, Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals, Nanjing Forestry University (NFU), Nanjing 210037 PR China. Electronic address: huangchaobo@njfu.edu.cn.

PMID: 27474676
DOI: 10.1016/j.carbpol.2016.06.066

Abstract

In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27±2.32MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2±0.03MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for "semen sensitive" (intravaginal) drug delivery.

Keywords: Cellulose acetate phthalate; Core-shell electrospinning; Intravaginal drug delivery; Polyurethane.

MeSH terms

Animals
Cell Line
Cellulose / analogs & derivatives*
Cellulose / chemistry
Drug Carriers / chemistry*
Drug Carriers / toxicity
Drug Liberation
Electricity*
Female
Hydrogen-Ion Concentration
Mechanical Phenomena
Mice
Polyurethanes / chemistry*
Rhodamines / chemistry
Vagina / metabolism*

Substances

Drug Carriers
Polyurethanes
Rhodamines
Cellulose
cellulose acetate phthalate