The early years of lipoprotein research: from discovery to clinical application

Abstract

This review outlines major milestones in the first four decades of lipoprotein research beginning with their discovery nearly 90 years ago. It focuses on the contributions of some of the key investigators during this era, and findings that set the stage for widespread clinical implementation of lipoprotein testing for evaluation and management of CVD risk.

Keywords: atherosclerosis; cholesterol; history; low density lipoprotein.