Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)

Alberto Cauli; Matteo Piga; Alberto Floris; Alessandro Mathieu

doi:10.2147/ITT.S62870

Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)

Immunotargets Ther. 2015 Oct 1:4:185-90. doi: 10.2147/ITT.S62870. eCollection 2015.

Authors

Alberto Cauli¹, Matteo Piga¹, Alberto Floris¹, Alessandro Mathieu¹

Affiliation

¹ Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy.

Abstract

TH17 is a lymphocyte subset, which is characterized by its polarization to secrete interleukin (IL)-17. IL-23 is the pivotal mediator responsible for TH17 differentiation and the IL-23/IL-17 axis has been strongly implicated in the pathogenesis of several immune mediated diseases, in particular chronic arthritis and skin psoriasis. This review will summarize the basic immunology and the new monoclonal antibodies, which antagonize this pathway allowing a new therapeutic approach.

Keywords: IL-17; IL-23; TH17; ankylosing spondylitis; psoriasis; psoriatic arthritis.

Publication types

Review