Polydatin induces bone marrow stromal cells migration by activation of ERK1/2

Biomed Pharmacother. 2016 Aug:82:49-53. doi: 10.1016/j.biopha.2016.04.059. Epub 2016 May 6.

Abstract

Bone marrow stromal cells (BMSCs) have proven to be useful for the treatment of numerous human diseases. However, the reparative ability of BMSCs is limited by their poor migration. Polydatin, widely used in traditional Chinese remedies, has proven to exert protective effects to BMSCs. However, little is known about its role in BMSCs migration. In this study, we studied the effects of polydatin on rat BMSCs migration using the scratch wound healing and transwell migration assays. Our results showed polydatin could promote BMSCs migration. Further experiments showed activation of ERK 1/2, but not JNK, was required for polydatin-induced BMSCs migration, suggesting that polydatin may promote BMSCs migration via the ERK 1/2 signaling pathways. Taken together, our results indicate that polydatin might be beneficial for stem cell replacement therapy by improving BMSCs migration.

Keywords: BMSCs; ERK 1/2; Migration; Polydatin.

MeSH terms

  • Animals
  • Cell Movement / drug effects*
  • Cell Shape / drug effects
  • Enzyme Activation / drug effects
  • Extracellular Signal-Regulated MAP Kinases / metabolism*
  • Glucosides / pharmacology*
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Male
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / drug effects
  • Mesenchymal Stem Cells / enzymology*
  • Phosphorylation / drug effects
  • Rats, Sprague-Dawley
  • Stilbenes / pharmacology*

Substances

  • Glucosides
  • Stilbenes
  • Extracellular Signal-Regulated MAP Kinases
  • JNK Mitogen-Activated Protein Kinases
  • polydatin