Stereoselective synthesis of strained cage compounds via gold-catalyzed allene functionalization

Benito Alcaide; Pedro Almendros; Sara Cembellín; Israel Fernández; Teresa Martínez Del Campo

doi:10.1039/c6cc03779h

Stereoselective synthesis of strained cage compounds via gold-catalyzed allene functionalization

Chem Commun (Camb). 2016 Aug 11;52(67):10265-8. doi: 10.1039/c6cc03779h.

Authors

Benito Alcaide¹, Pedro Almendros², Sara Cembellín¹, Israel Fernández³, Teresa Martínez Del Campo¹

Affiliations

¹ Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, 28040-Madrid, Spain. alcaideb@quim.ucm.es.
² Instituto de Química Orgánica General, IQOG-CSIC, Juan de la Cierva 3, 28006-Madrid, Spain. Palmendros@iqog.csic.es.
³ Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense de Madrid, 28040 Madrid, Spain.

PMID: 27468860
DOI: 10.1039/c6cc03779h

Abstract

The diastereoselective synthesis of strained adducts that show cage-like structures has been accomplished directly from allenyl-β-lactams through gold catalysis.