Modulation of Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment

Olga Papadodima; Panagiotis Moulos; Aggeliki Koryllou; Georgia Piroti; Fragiskos Kolisis; Aristotelis Chatziioannou; Vasiliki Pletsa

doi:10.1371/journal.pone.0160248

Modulation of Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment

PLoS One. 2016 Jul 28;11(7):e0160248. doi: 10.1371/journal.pone.0160248. eCollection 2016.

Authors

Olga Papadodima¹, Panagiotis Moulos², Aggeliki Koryllou¹, Georgia Piroti¹, Fragiskos Kolisis³, Aristotelis Chatziioannou^{1

4}, Vasiliki Pletsa¹

Affiliations

¹ Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece.
² Institute of Molecular Biology and Genetics, Biomedical Sciences Research Centre 'Alexander Fleming', 16672 Vari, Greece.
³ Laboratory of Biotechnology, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece.
⁴ Enios Applications Private Company, 25 Al.Pantou str., 17671 Athens, Greece.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
Alkylating Agents / pharmacology
Blotting, Western
Carcinoma, Non-Small-Cell Lung / genetics
Carcinoma, Non-Small-Cell Lung / metabolism
Carcinoma, Non-Small-Cell Lung / pathology
Cell Death / genetics
Cell Line, Tumor
Dacarbazine / analogs & derivatives
Dacarbazine / pharmacology
Gene Expression Profiling / methods*
Gene Expression Regulation, Neoplastic / drug effects*
Gene Ontology
Humans
Lung Neoplasms / genetics
Lung Neoplasms / metabolism
Lung Neoplasms / pathology
Methylnitrosourea / pharmacology*
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / drug effects*
Signal Transduction / genetics
Temozolomide

Substances

Alkylating Agents
Methylnitrosourea
Dacarbazine
Temozolomide

Grants and funding

This project was co- financed by E.U.-European Social Fund (75%) and the General Secretariat for Research and Technology (www.gsrt.gr), Greece (25%); PENED 03/ΕΔ/322 and PROMISE, 12CHN 204. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.