The Role of FOXP3 in Human Cancers

Anticancer Res. 2016 Aug;36(8):3789-94.

Abstract

FOXP3 transcription factor can be observed as the main component of the immune system expressed in regulatory T (Treg) cells that regulate hemostasis and self-tolerance. Moreover, the altered expression of FOXP3 was found in autoimmune diseases, benign tumors and carcinomas. Latest reports indicate that the FOXP3 gene mutation can contribute to carcinogenesis, which can be associated with immune response abnormalities. Infiltration of the Treg cells into tumor cells can be associated with prognosis. Understanding the biology of the FOXP3 gene may be crucial in developing new immunotherapeutics.

Keywords: FOXP3; cancer; review; tumor immunity.

Publication types

  • Review

MeSH terms

  • Forkhead Transcription Factors / biosynthesis
  • Forkhead Transcription Factors / genetics*
  • Forkhead Transcription Factors / immunology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunotherapy*
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Prognosis
  • T-Lymphocytes, Regulatory / immunology

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors