Abstract
The zebrafish has emerged as an important model organism for understanding the cellular and molecular mechanisms of tissue regeneration. Adult zebrafish efficiently replace cardiac muscle after partial resection of their ventricle, or after transgenic ablation of cardiomyocytes. Here, we describe methodology for inducing these injuries and assaying indicators of regeneration.
Keywords:
Ablation; Cardiomyocyte; Heart; Regeneration; Surgery; Zebrafish.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Biological Assay / methods*
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Heart / physiology*
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Heart / physiopathology*
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Heart Injuries / metabolism
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Heart Injuries / pathology
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Heart Injuries / physiopathology*
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Heart Ventricles / metabolism
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Heart Ventricles / pathology
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Heart Ventricles / physiopathology
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Myocardium / metabolism
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Myocardium / pathology
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Myocytes, Cardiac / cytology
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Myocytes, Cardiac / physiology
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Regeneration / genetics
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Regeneration / physiology*
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Signal Transduction / physiology
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Wound Healing / physiology
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Zebrafish
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Zebrafish Proteins / genetics
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Zebrafish Proteins / metabolism*