Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams

Org Biomol Chem. 2016 Aug 10;14(32):7731-4. doi: 10.1039/c6ob01126h.

Abstract

A method for the palladium-catalyzed arylation of α,β-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.

MeSH terms

  • Catalysis
  • Hydrocarbons, Brominated / chemical synthesis*
  • Hydrocarbons, Brominated / chemistry
  • Lactams / chemistry*
  • Molecular Structure
  • Palladium / chemistry*

Substances

  • Hydrocarbons, Brominated
  • Lactams
  • valerolactam
  • Palladium