Tuning the MYC response

Elife. 2016 Jul 27:5:e18871. doi: 10.7554/eLife.18871.

Abstract

Altering the ability of the MYC transcription factor to bind to individual genes can customize the global gene expression output of cells.

Keywords: ChIP-sequencing; MIZ1; MYC; WDR5; cancer biology; cell biology; human; mathematical modeling; mouse; promoter affinity.

Publication types

  • Comment

MeSH terms

  • Gene Expression*
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-myc / genetics*
  • Transcription Factors / genetics

Substances

  • Proto-Oncogene Proteins c-myc
  • Transcription Factors