Validity of the Portuguese CHO-KLAT in Brazil

P R Villaça; V S Blanchette; J D A Carneiro; M C Ozelo; S Antunes; B M Feldman; A Abad; K Usuba; N L Young

doi:10.1111/hae.13031

Validity of the Portuguese CHO-KLAT in Brazil

Haemophilia. 2016 Nov;22(6):894-897. doi: 10.1111/hae.13031. Epub 2016 Jul 25.

Authors

P R Villaça¹, V S Blanchette², J D A Carneiro³, M C Ozelo⁴, S Antunes⁵, B M Feldman⁶, A Abad⁷, K Usuba⁸, N L Young⁹

Affiliations

¹ Service of Hematology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
² Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
³ Centro de Hemofilia e Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
⁴ Unit of Hemophilia IHTC, Cláudio L.P. Correa, Hemocentro Unicamp, INCT do Sangue, University of Campinas, Campinas, Brazil.
⁵ Department of Hematology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
⁶ Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.
⁷ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
⁸ Evaluating Children's Health Outcomes Research Centre, Laurentian University, Sudbury, ON, Canada.
⁹ School of Rural and Northern Health, Laurentian University, Sudbury, ON, Canada.

PMID: 27456858
DOI: 10.1111/hae.13031

Abstract

Introduction: It is essential to assess the health-related quality of life outcomes of boys with haemophilia in Brazil. The Canadian Haemophilia Outcomes-Kids Life Assessment Tool (CHO-KLAT) was recently adapted for this population.

Aim: To test the construct validity of the Portuguese version of the CHO-KLAT.

Methods: We recruited 50 boys, with moderate [factor VIII (FVIII) level 1-5%] or severe (FVIII level <1%) haemophilia, to participate in a descriptive study to establish a baseline understanding of the current status of boys with haemophilia in Brazil. All boys were required to complete the Brazilian CHO-KLAT and Brazilian Pediatric Quality of Life Inventory (PedsQL) by self-report. We examined the correlation between the CHO-KLAT and PedsQL scores to establish the construct validity of the Brazilian version of the CHO-KLAT.

Results: We obtained CHO-KLAT and PedsQL data from 35 boys with severe haemophilia and 15 with moderate haemophilia. They ranged in age from 7.3 to 18.0 years, with a mean of 13.0 years. They reported a mean CHO-KLAT score of 72.3 (range = 44.1-93.9). The mean PedsQL score was 79.9 (range = 45.7-96.7), with physical health (mean of 83.9) being better than psychosocial health (77.8). The Pearson's correlation between CHO-KLAT and PedsQL was 0.47 respectively (P < 0.001). The CHO-KLAT had a moderate and inverse relationship with the degree to which they were bothered by their haemophilia (ρ = -0.53), while the PedsQL had a weaker relationship (ρ = -0.27).

Conclusion: The results confirm the validity of the Portuguese version of the CHO-KLAT. This measure is now available for clinical trials in boys with haemophilia in Brazil.

Keywords: haemophilia; outcome measurement; paediatrics; quality of life.

MeSH terms

Adolescent
Brazil
Child
Hemophilia A / drug therapy*
Humans
Male
Outcome Assessment, Health Care / methods*
Quality of Life