Magnetic nanomaterials and sensors for biological detection

Agnieszka Sobczak-Kupiec; Jayachandran Venkatesan; Adnan Alhathal AlAnezi; Dorota Walczyk; Ammad Farooqi; Dagmara Malina; Seyed Hossein Hosseini; Bozena Tyliszczak

doi:10.1016/j.nano.2016.07.003

Magnetic nanomaterials and sensors for biological detection

Nanomedicine. 2016 Nov;12(8):2459-2473. doi: 10.1016/j.nano.2016.07.003. Epub 2016 Jul 25.

Authors

Agnieszka Sobczak-Kupiec¹, Jayachandran Venkatesan², Adnan Alhathal AlAnezi³, Dorota Walczyk⁴, Ammad Farooqi⁵, Dagmara Malina⁴, Seyed Hossein Hosseini⁶, Bozena Tyliszczak⁷

Affiliations

¹ Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland. Electronic address: asobczak@chemia.pk.edu.pl.
² Department of Chemistry, Marine Bio process Research Center, Pukyong National University, Busan, South Korea. Electronic address: venkatjchem@pknu.ac.kr.
³ Department of Chemical Engineering Technology, College of Technological Studies, The Public Authority for Applied Education and Training (PAAET), Sabah Alsalem, Kuwait. Electronic address: aa.alanezi@paaet.edu.kw.
⁴ Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland.
⁵ Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Electronic address: ammadfarooqi@rlmclahore.com.
⁶ Department of Chemistry, Faculty of Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address: hosseini_sh44@yahoo.com.
⁷ Cracow University of Technology, Department of Polymer Chemistry and Technology, Cracow, Poland. Electronic address: btyliszczak@chemia.com.

PMID: 27456162
DOI: 10.1016/j.nano.2016.07.003

Abstract

It is becoming progressively more understandable that sensitivity and versatility of magnetic biosensors provides unique platform for high performance diagnostics in clinical settings. Confluence of information suggested that magnetic biosensors required well-tailored magnetic particles as probes for detection that generate large and specific biological signal with minimum possible nonspecific binding. However, there are visible knowledge gaps in our understanding of the strategies to overcome existing challenges related to even smaller size of intracellular targets and lower signal-to-noise ratio than that in whole-cell studies, therefore tool designing and development for intracellular measurement and manipulation is problematic. In this review we describe magnetic nanoparticles, synthesis and sensing principles of magnetic nanoparticles as well as surface functionalization and modification and finally magnetic nanoparticles for medical diagnostics. This review gathers important and up-to-date information and may help to develop the method of obtaining magnetic materials especially for medical application.

Keywords: Magnetic nanoparticles; Magnetic nanoparticles for medical diagnostics; Sensing principles of magnetic nanoparticles; Surface functionalization and modification; Synthesis.

Publication types

Review

MeSH terms

Biosensing Techniques*
Magnetics*
Nanoparticles
Nanostructures*
Signal-To-Noise Ratio