New Genetics and Genomic Data on Pancreatic Neuroendocrine Tumors: Implications for Diagnosis, Treatment, and Targeted Therapies

Endocr Pathol. 2016 Sep;27(3):200-4. doi: 10.1007/s12022-016-9447-2.

Abstract

The recent findings on the roles of death-associated protein 6/α-thalassemia/mental retardation X-linked (DAXX/ATRX) in the development of pancreatic neuroendocrine tumors (PanNETs) have led to major advances in the molecular understanding of these rare tumors and open up completely new therapeutic windows. This overview aims at giving a simplified view on these findings and their possible therapeutic implications. The importance of epigenetic changes in PanNET is also underlined by recent findings of a cross-species study on microRNA (miRNA) and messenger RNA (mRNA) profiles in PanNETs.

Keywords: Alternative lengthening of telomeres; DAXX/ATRX; Epigenetics; Methylation; Pancreatic neuroendocrine tumor; Review.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Animals
  • Co-Repressor Proteins
  • Genomics
  • Humans
  • Molecular Chaperones
  • Molecular Targeted Therapy / methods
  • Molecular Targeted Therapy / trends
  • Neuroendocrine Tumors / diagnosis
  • Neuroendocrine Tumors / genetics*
  • Neuroendocrine Tumors / therapy
  • Nuclear Proteins / genetics
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / therapy

Substances

  • Adaptor Proteins, Signal Transducing
  • Co-Repressor Proteins
  • DAXX protein, human
  • Molecular Chaperones
  • Nuclear Proteins