Zalocusky et al. (Nature 531:642-646, 2016) recently showed that activity in D2R+ cells in the nucleus accumbens is associated with loss sensitivity to prior outcomes and reduced subsequent risky choice, and that optogenetic stimulation of these cells decreased risky choices in risk-prone rats. While their findings are important for understanding trait-level risk-taking, future research should aim to examine the neuronal mechanisms of a broader range of facets of gain and loss processing with respect to different potential reference points.
Keywords: Dopamine; Loss sensitivity; Nucleus accumbens; Probability discounting; Risky choice.