Microalbuminuria in non diabetic population as an marker of nephropathy

J Bras Nefrol. 2016 Jun;38(2):203-8. doi: 10.5935/0101-2800.20160029.
[Article in English, Portuguese]

Abstract

Introduction: Years before the progression to diabetes mellitus type II patients can get by with a pre-diabetes called period. The pathogenesis involved pre-diabetes is insulin resistance Objective: This paper discusses the frequency of microalbuminuria in non-diabetic population, but with increased metabolic risk, and attempts to assess whether there is any correlation of microalbuminuria with data from glucose metabolism.

Methods: A total of 132 nondiabetic patients who presented one or more risk factors for changes in glucose metabolism were included in the study: arterial hypertension; obesity; first-degree relatives with diabetes; individuals of Hispanic-American, Asian and African-American ethnicities; mothers of newborns who are large for gestational age (LGA) or who had gestational diabetes; serum measurements in fasting HDL cholesterol 250 mg/dL.

Results: The results showed a frequency of abnormal microalbuminuria for the method in 16% of this population, and the presence of lower levels of HDL-cholesterol and creatinine clearance in this population. There was a positive correlation between microalbuminury and serum creatinine and uric acid.

Conclusion: Our study suggests that microalbuminuria be evaluated as a marker of incipient nephropathy in non-diabetic population with increased metabolic risk.

MeSH terms

  • Albuminuria / complications
  • Albuminuria / metabolism*
  • Albuminuria / physiopathology*
  • Cross-Sectional Studies
  • Female
  • Glucose / metabolism
  • Humans
  • Kidney Diseases / etiology
  • Male
  • Middle Aged
  • Prediabetic State*
  • Risk Factors

Substances

  • Glucose