The authors describe the principal difficulties and intra and post-operative complications frequently encountered in IOL implantation surgery in P.C. in patients with pseudoexfoliation syndrome (SPE); particular attention is given to incomplete mydriasis, the facilitation of expulsion by sphyncterotomy or radial iridotomy, zonule rupture, uveal retraction, endothelial involvement, hyphema and lens dislocation. These complications were more numerous in patients with SPE plus glaucoma. The authors conclude that, with adequate pre-operative investigation and appropriate measures during surgery, SPE with or without glaucoma is not to be considered an absolute contraindication to IOL implantation in P.C.