The thermal conductivity of a single ZnO nanowire with diameter of ~150 nm was measured using a four-point-probe 3omega method over a temperature range of 140-300 K. The measured ther- mal conductivity of ZnO nanowire is strongly reduced compared to bulk ZnO crystal due to the enhanced phonon-boundary and impurity (isotope) scattering. The maximum of the thermal conductivity is shifted to a higher temperature than that of bulk counterpart. Temperature dependent measurements show that beyond the low-temperature maximum, the thermal conductivity decreases with temperature as T(-1.5) indicating strong impurity (isotope) scattering at intermediate and high temperatures.