Cortactin enhances exosome secretion without altering cargo

Lahiru Gangoda; Suresh Mathivanan

doi:10.1083/jcb.201606131

Cortactin enhances exosome secretion without altering cargo

J Cell Biol. 2016 Jul 18;214(2):129-31. doi: 10.1083/jcb.201606131.

Authors

Lahiru Gangoda¹, Suresh Mathivanan²

Affiliations

¹ Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.
² Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia s.mathivanan@latrobe.edu.au.

Abstract

The role of cortactin, a regulator of late endosomal trafficking, in the biogenesis and secretion of exosomes is poorly understood. In this issue, Sinha et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601025) elucidate the role of cortactin as a positive regulator of late endosomal docking and exosome secretion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actin-Related Protein 2-3 Complex / metabolism
Biological Transport
Cell Line, Tumor
Cortactin / metabolism*
Exosomes / metabolism*
Humans

Substances

Actin-Related Protein 2-3 Complex
Cortactin