Acute Myeloid Leukemia in Children: Experience from Tertiary Cancer Centre in India

Venkatraman Radhakrishnan; Cherian Thampy; Prasanth Ganesan; Rejiv Rajendranath; Trivadi S Ganesan; K R Rajalekshmy; Tenali Gnana Sagar

doi:10.1007/s12288-015-0591-5

Acute Myeloid Leukemia in Children: Experience from Tertiary Cancer Centre in India

Indian J Hematol Blood Transfus. 2016 Sep;32(3):257-61. doi: 10.1007/s12288-015-0591-5. Epub 2015 Sep 18.

Authors

Venkatraman Radhakrishnan¹, Cherian Thampy¹, Prasanth Ganesan¹, Rejiv Rajendranath¹, Trivadi S Ganesan¹, K R Rajalekshmy², Tenali Gnana Sagar¹

Affiliations

¹ Departments of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai India.
² Department of Pathology, Cancer Institute (WIA), Adyar, Chennai India.

Abstract

There is paucity of data in pediatric Acute Myeloid Leukemia (AML) from developing countries. We analyzed the outcomes of 65 consecutive patients with pediatric AML treated at our centre from January-2008 to May-2013. The median event free survival (EFS) and overall survival (OS) were 12.6 and 14.6 months respectively. Patients with good-risk cytogenetics had a better EFS (p = 0.004) and OS (p = 0.01). Overall, these results are not comparable to that observed in other centres globally and leaves scope for further improvement. This includes implementing allogeneic bone marrow transplantation as a treatment for all children with high-risk AML.

Keywords: Acute Myeloid Leukemia; Chemotherapy; Survival.