Abstract
Five new compounds, named ancistronaphtosides A and B (1 and 2), anciscochine (3), anciscochine 6-O-β-d-glucopyranoside (4), and 4'-methoxy-5-epi-ancistecrorine A1 (5), together with tortoside A (6) and 4-hydroxy-2-methoxyphenyl-6-O-syringoyl-β-d-glucopyranoside (7) were isolated from the methanolic extract of Ancistrocladus cochinchinensis. Their chemical structures were established using HR-ESI-MS, NMR spectroscopic, and chiroptical methods. Compound 5 significantly exhibited anti-proliferation against HL-60, LU-1, and SK-MEL-2 cells with IC50 values of 5.0±1.2, 6.5±1.6, and 6.8±2.0μg/mL, respectively.
Keywords:
Ancistrocladus cochinchinensis; Anti-proliferation; Isoquinoline alkaloid; Naphthalene derivative.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / toxicity
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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HL-60 Cells
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Humans
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Isoquinolines / chemistry*
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Magnoliopsida / metabolism
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Molecular Conformation
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Naphthalenes / chemistry*
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Naphthalenes / isolation & purification
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Naphthalenes / toxicity
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Neoplasms / metabolism
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Neoplasms / pathology
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Plant Extracts / chemistry
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Spectrometry, Mass, Electrospray Ionization
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Isoquinolines
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Naphthalenes
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Plant Extracts
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isoquinoline