This systematic review aims to analyze molecular markers of cancer stem cells. Only studies that confirmed tumor-initiating capacity of this population by in vivo assay in immunodeficient mice were included. Final sample of papers that fully correspond with initial aim consists of 97 original studies. The results of their analysis reveal that markers commonly used for cancer stem cells deriving were as follows: CD133, СD44, ALDH, CD34, CD24 and EpCAM. The review also contains description of molecular features of some cancer stem cell markers, modern approaches to cancer treatment by targeting this population and brief assessment of cancer stem cell theory development.
Sistemnyĭ obzor posviashchen vyiavleniiu molekuliarnykh markerov rakovykh stvolovykh kletok, znachimost' kotorykh podtverzhdena v éksperimentakh po transplantatsii opukholevykh subpopuliatsiĭ s razlichnym fenotipom immunodefitsitnym zhivotnym. Bylo otobrano 97 stateĭ, polnost'iu sootvetstvuiushchikh zadacham issledovaniia. Rezul'taty ikh analiza svidetel'stvuiut, chto naibolee chasto ispol'zuemymi dlia vydeleniia rakovykh stvolovykh kletok markerami iavliaiutsia: CD133, SD44, ALDH, CD34, CD24 i EpCAM. V obzore takzhe privedeny molekuliarnye osobennosti i svoĭstva riada markerov rakovykh stvolovykh kletok, rassmatrivaiutsia podkhody k terapii opukholeĭ, napravlennye protiv étoĭ kletochnoĭ subpopuliatsii, otsenivaiutsia perspektivy dal'neĭshego razvitiia teorii rakovoĭ stvolovoĭ kletki.
Keywords: cancer stem cell; molecular markers; systemic review.