Blocking collagen fibril formation in injured knees reduces flexion contracture in a rabbit model

J Orthop Res. 2017 May;35(5):1038-1046. doi: 10.1002/jor.23369. Epub 2016 Jul 29.

Abstract

Post-traumatic joint contracture is a frequent orthopaedic complication that limits the movement of injured joints, thereby severely impairing affected patients. Non-surgical and surgical treatments for joint contracture often fail to improve the range of motion. In this study, we tested a hypothesis that limiting the formation of collagen-rich tissue in the capsules of injured joints would reduce the consequences of the fibrotic response and improve joint mobility. We targeted the formation of collagen fibrils, the main component of fibrotic deposits formed within the tissues of injured joints, by employing a relevant rabbit model to test the utility of a custom-engineered antibody. The antibody was delivered directly to the cavities of injured knees in order to block the formation of collagen fibrils produced in response to injury. In comparison to the non-treated control, mechanical tests of the antibody-treated knees demonstrated a significant reduction of flexion contracture. Detailed microscopic and biochemical studies verified that this reduction resulted from the antibody-mediated blocking of the assembly of collagen fibrils. These findings indicate that extracellular processes associated with excessive formation of fibrotic tissue represent a valid target for limiting post-traumatic joint stiffness. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1038-1046, 2017.

Keywords: antibody; arthrofibrosis; collagen fibrils; joint contracture; posterior capsule collagen.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Antibodies / pharmacology
  • Antibodies / therapeutic use*
  • Collagen Type I / antagonists & inhibitors
  • Collagen Type III / metabolism
  • Contracture / etiology
  • Contracture / prevention & control*
  • Feasibility Studies
  • Female
  • Fibrillar Collagens / metabolism*
  • Knee Injuries / complications
  • Knee Injuries / metabolism
  • Knee Injuries / therapy*
  • Rabbits
  • Recombinant Proteins / pharmacology
  • Recombinant Proteins / therapeutic use

Substances

  • Antibodies
  • Collagen Type I
  • Collagen Type III
  • Fibrillar Collagens
  • Recombinant Proteins