(1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

P E Menschikov; N A Semenova; M V Ublinskiy; T A Akhadov; R A Keshishyan; I S Lebedeva; M A Omelchenko; V G Kaleda; S D Varfolomeev

doi:10.1134/S1607672916030029

(1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

Dokl Biochem Biophys. 2016 May;468(1):168-72. doi: 10.1134/S1607672916030029. Epub 2016 Jul 15.

Authors

P E Menschikov¹, N A Semenova^{2

3

4}, M V Ublinskiy^{2

3}, T A Akhadov³, R A Keshishyan³, I S Lebedeva⁵, M A Omelchenko⁵, V G Kaleda⁵, S D Varfolomeev²

Affiliations

¹ Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia. peeterem@gmail.com.
² Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia.
³ Research Institute of Emergency Children's Surgery and Trauma, Bol'shaya Polyanka 22, Moscow, 119180, Russia.
⁴ Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia.
⁵ Scientific Center of Mental Health, Moscow, Russia.

PMID: 27417711
DOI: 10.1134/S1607672916030029

Abstract

The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.

MeSH terms

Adolescent
Adult
Creatine / metabolism
Frontal Lobe / diagnostic imaging
Frontal Lobe / metabolism*
Functional Laterality
Glutamic Acid / metabolism*
Glutamine / metabolism*
Humans
Male
Prodromal Symptoms
Proton Magnetic Resonance Spectroscopy / methods*
Risk
Schizophrenia / diagnostic imaging
Schizophrenia / metabolism*
Young Adult
gamma-Aminobutyric Acid / metabolism*

Substances

Glutamine
Glutamic Acid
gamma-Aminobutyric Acid
Creatine