Abstract
Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers the mechanisms that play a significant role in AML cell malignant transformation and shows the contributions of certain genes to both remission and resistance of AML cells to various treatments.
Keywords:
DNA repair; Hedgehog; JNK; TGF-β; acute myeloid leukemia; apoptosis; cancer; p38; signaling pathways.
MeSH terms
-
Antineoplastic Agents / therapeutic use
-
Apoptosis / drug effects
-
Apoptosis / genetics
-
Caspases / genetics
-
Caspases / metabolism
-
Cell Transformation, Neoplastic / genetics*
-
Cell Transformation, Neoplastic / metabolism
-
Cell Transformation, Neoplastic / pathology
-
Drug Resistance, Neoplasm / genetics
-
Gene Expression Regulation, Neoplastic*
-
Granulocytes / drug effects
-
Granulocytes / metabolism
-
Granulocytes / pathology
-
Hedgehog Proteins / genetics
-
Hedgehog Proteins / metabolism
-
Humans
-
Leukemia, Myeloid, Acute / drug therapy
-
Leukemia, Myeloid, Acute / genetics*
-
Leukemia, Myeloid, Acute / metabolism
-
Leukemia, Myeloid, Acute / pathology
-
Mitochondria / drug effects
-
Mitochondria / metabolism
-
Mitochondria / pathology
-
Neoplasm Proteins / genetics*
-
Neoplasm Proteins / metabolism
-
Proto-Oncogene Proteins c-bcl-2 / genetics
-
Proto-Oncogene Proteins c-bcl-2 / metabolism
-
Remission Induction
-
Signal Transduction / genetics*
-
bcl-2-Associated X Protein / genetics
-
bcl-2-Associated X Protein / metabolism
Substances
-
Antineoplastic Agents
-
BAX protein, human
-
BCL2 protein, human
-
Hedgehog Proteins
-
Neoplasm Proteins
-
Proto-Oncogene Proteins c-bcl-2
-
SHH protein, human
-
bcl-2-Associated X Protein
-
Caspases