Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery

Abstract

Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.

Keywords: drug delivery; nanoparticles; optical imaging; renal clearance; theranostics.