Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013

Mineji Hayakawa; Shinjiro Saito; Shigehiko Uchino; Kazuma Yamakawa; Daisuke Kudo; Yusuke Iizuka; Masamitsu Sanui; Kohei Takimoto; Toshihiko Mayumi; Takeo Azuhata; Fumihito Ito; Shodai Yoshihiro; Katsura Hayakawa; Tsuyoshi Nakashima; Takayuki Ogura; Eiichiro Noda; Yoshihiko Nakamura; Ryosuke Sekine; Yoshiaki Yoshikawa; Motohiro Sekino; Keiko Ueno; Yuko Okuda; Masayuki Watanabe; Akihito Tampo; Nobuyuki Saito; Yuya Kitai; Hiroki Takahashi; Iwao Kobayashi; Yutaka Kondo; Wataru Matsunaga; Sho Nachi; Toru Miike; Hiroshi Takahashi; Shuhei Takauji; Kensuke Umakoshi; Takafumi Todaka; Hiroshi Kodaira; Kohkichi Andoh; Takehiko Kasai; Yoshiaki Iwashita; Hideaki Arai; Masato Murata; Masahiro Yamane; Kazuhiro Shiga; Naoto Hori

doi:10.1186/s40560-016-0169-9

Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013

J Intensive Care. 2016 Jul 12:4:44. doi: 10.1186/s40560-016-0169-9. eCollection 2016.

Authors

Mineji Hayakawa¹, Shinjiro Saito², Shigehiko Uchino², Kazuma Yamakawa³, Daisuke Kudo⁴, Yusuke Iizuka⁵, Masamitsu Sanui⁶, Kohei Takimoto⁷, Toshihiko Mayumi⁸, Takeo Azuhata⁹, Fumihito Ito¹⁰, Shodai Yoshihiro¹¹, Katsura Hayakawa¹², Tsuyoshi Nakashima¹³, Takayuki Ogura¹⁴, Eiichiro Noda¹⁵, Yoshihiko Nakamura¹⁶, Ryosuke Sekine¹⁷, Yoshiaki Yoshikawa³, Motohiro Sekino¹⁸, Keiko Ueno¹⁹, Yuko Okuda²⁰, Masayuki Watanabe²¹, Akihito Tampo²², Nobuyuki Saito²³, Yuya Kitai²⁴, Hiroki Takahashi²⁵, Iwao Kobayashi²⁶, Yutaka Kondo²⁷, Wataru Matsunaga⁶, Sho Nachi²⁸, Toru Miike²⁹, Hiroshi Takahashi³⁰, Shuhei Takauji³¹, Kensuke Umakoshi³², Takafumi Todaka³³, Hiroshi Kodaira³⁴, Kohkichi Andoh³⁵, Takehiko Kasai³⁶, Yoshiaki Iwashita³⁷, Hideaki Arai⁸, Masato Murata³⁸, Masahiro Yamane³⁹, Kazuhiro Shiga⁴⁰, Naoto Hori⁴¹

Affiliations

¹ Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, 060-8648 Japan.
² Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
³ Department of Emergency and Critical Care, Osaka General Medical Center, Osaka, Japan.
⁴ Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
⁵ Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan ; Department of Critical Care, Shonan Kamakura General Hospital, Kamakura, Japan.
⁶ Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
⁷ Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
⁸ Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
⁹ Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan.
¹⁰ Department of Emergency and Critical Care Medicine, Ohta General Hospital Foundation, Ohta Nishinouchi Hospital, Koriyama, Japan.
¹¹ Pharmaceutical Department, JA Hiroshima General Hospital, Hiroshima, Japan.
¹² Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, Saitama, Japan.
¹³ Department of Emergency and Critical Care Medicine, Wakayama Medical University, Wakayama, Japan.
¹⁴ Department of Emergency Medicine and Critical Care Medicine, Advanced Medical Emergency Department and Critical Care Center, Japan Red Cross Maebashi Hospital, Maebashi, Japan.
¹⁵ Emergency and Critical Care Center, Kyushu University Hospital, Fukuoka, Japan.
¹⁶ Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
¹⁷ Emergency Department, Ibaraki Prefectural Central Hospital, Kasama, Japan.
¹⁸ Division of Intensive Care, Nagasaki University Hospital, Nagasaki, Japan.
¹⁹ Department of Emergency and Critical Care Medicine, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan.
²⁰ Department of Emergency and Critical Care Medicine, Kyoto Daiichi Red Cross Hospital, Kyoto, Japan.
²¹ Intensive Care Unit, Saiseikai Yokohamasi Tobu Hospital, Yokohama, Japan.
²² Department of Emergency Medicine, Asahikawa Medical University, Asahikawa, Japan.
²³ Shock and Trauma Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
²⁴ Emergency Medicine, Kameda Medical Center, Kamogawa, Japan.
²⁵ Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
²⁶ Emergency and Critical Care Medicine, Asahikawa Red Cross Hospital, Asahikawa, Japan.
²⁷ Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
²⁸ Advanced Critical Care Center, Gifu University Hospital, Gifu, Japan.
²⁹ Emergency and Critical Care Center, Saga University Hospital, Saga, Japan.
³⁰ The Division of Cardiovascular Disease, Steel Memorial Muroran Hospital, Muroran, Japan.
³¹ Department of Emergency Medicine and Critical Care, Sapporo City General Hospital, Sapporo, Japan.
³² Division of Emergency Medicine, Ehime University Hospital, Toon, Japan.
³³ Intensive Care Unit, Tomishiro Central Hospital, Tomishiro, Japan.
³⁴ Department of Emergency Medicine, Akashi City Hospital, Akashi, Japan.
³⁵ Department of Emergency and Critical Care, Sendai City Hospital, Sendai, Japan.
³⁶ Emergency Department, Hakodate Municipal Hospital, Hakodate, Japan.
³⁷ Emergency and Critical Care Center, Mie University Hospital, Tsu, Japan.
³⁸ Department of Emergency Medicine, Gunma University, Maebashi, Japan.
³⁹ Department of Anesthesia and Intensive Care, KKR Sapporo Medical Center, Sapporo, Japan.
⁴⁰ Emergency and Critical Care Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
⁴¹ Intensive Care Unit, Hyogo College of Medicine, Nishinomiya, Japan.

Abstract

Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sepsis in 42 ICUs throughout Japan. The patients with severe sepsis had a mean age of 70 ± 15 years and a mean Acute Physiology and Chronic Health Evaluation II score of 23 ± 9. The estimated survival rates at 28 and 90 days after ICU admission were 73.6 and 56.3 %, respectively.

Keywords: Acute kidney injury; Acute respiratory failure; Disseminated intravascular coagulation; Epidemiology; Mortality; Organ failure; Septic shock; Severe sepsis.