Lactate dehydrogenase (LD), alkaline phosphatase (ALP) isoenzymatic patterns in Iraqi children with visceral leishmaniasis before and after treatment with stibogluconate

Jasim Hameed Taher; Yassir Mustafa Kamal Al-Mulla Hummadi; Nada Muhammed Taha Al-Bashir; Ali Shaalan Al-Araji

doi:10.1007/s12639-014-0494-7

Lactate dehydrogenase (LD), alkaline phosphatase (ALP) isoenzymatic patterns in Iraqi children with visceral leishmaniasis before and after treatment with stibogluconate

J Parasit Dis. 2016 Jun;40(2):277-84. doi: 10.1007/s12639-014-0494-7. Epub 2014 Jun 22.

Authors

Jasim Hameed Taher¹, Yassir Mustafa Kamal Al-Mulla Hummadi², Nada Muhammed Taha Al-Bashir³, Ali Shaalan Al-Araji¹

Affiliations

¹ Department of Biology, College of Science, Babylon University, P.O. Box 4, Hilla, Babylon Iraq.
² Department of Pharmacology and Toxicology, College of Pharmacy, Al-Mustansiriyah University, P.O. Box 14070, Hay Al-Qadisiyah, Baghdad Iraq.
³ Leishmania Unit, Medical Research Centre, College of Medicine, Al-Nahrain University, P.O. Box 14222, Al-Kadhymia, Baghdad Iraq.

Abstract

The mean levels of alkaline phosphatase (ALP), lactate dehydrogenase enzymes exhibited a significant elevation in visceral leishmaniasis (VL) patients compared to the control. There was no significant change in relation to the sex and age. ALP isoenzymes revealed three banding patterns which differ from the three zymodems which were obtained from control group. These differences may be due to isoenzymes activity of patients with VL before and after therapy. Lactate dehydrogenase (LD) isoenzymes revealed five banding patterns differ from the five normal zymodems. These differences mainly occurred due to LD isoenzymes activity in patients with VL before and after therapy.

Keywords: Alkaline phosphatase (ALP); Isoenymatic patterns; Isoenzymes; Lactate dehydrogenase (LD); Visceral leishmaniasis (VL); Zymodems.