Human Papillomavirus Entry: Hiding in a Bubble

Stephen DiGiuseppe; Malgorzata Bienkowska-Haba; Martin Sapp

doi:10.1128/JVI.01065-16

Human Papillomavirus Entry: Hiding in a Bubble

J Virol. 2016 Aug 26;90(18):8032-5. doi: 10.1128/JVI.01065-16. Print 2016 Sep 15.

Authors

Stephen DiGiuseppe¹, Malgorzata Bienkowska-Haba¹, Martin Sapp²

Affiliations

¹ Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist-Weiller Cancer Center, LSU Health Shreveport, Shreveport, Louisiana, USA.
² Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist-Weiller Cancer Center, LSU Health Shreveport, Shreveport, Louisiana, USA msapp1@lsuhsc.edu.

Abstract

Incoming human papillomavirus (HPV) utilize vesicular transport to traffic from the plasma membrane to the trans-Golgi network. Following nuclear envelope breakdown during mitosis, the viral DNA associates with condensed chromosomes utilizing spindle microtubules for delivery. Most intriguingly, the viral DNA resides in a transport vesicle until mitosis is completed and the nuclear envelope has reformed. This finding provides support for the transient existence of nuclear membrane-bound vesicles. Due to their transient nature, it also points to the existence of a cell pathway for the disposal of vesicles ending up fortuitously or purposefully in the nucleus.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cytoplasmic Vesicles / virology
Endocytosis
Humans
Papillomaviridae / physiology*
Virus Internalization*

Abstract

Publication types

MeSH terms

Grants and funding