EXtended ACquisition Time (EXACT) NMR-A Case for 'Burst' Non-Uniform Sampling

Ikenna E Ndukwe; Alexandra Shchukina; Krzysztof Kazimierczuk; Carlos Cobas; Craig P Butts

doi:10.1002/cphc.201600541

EXtended ACquisition Time (EXACT) NMR-A Case for 'Burst' Non-Uniform Sampling

Chemphyschem. 2016 Sep 19;17(18):2799-803. doi: 10.1002/cphc.201600541. Epub 2016 Jul 14.

Authors

Ikenna E Ndukwe¹, Alexandra Shchukina^{2

3}, Krzysztof Kazimierczuk², Carlos Cobas⁴, Craig P Butts⁵

Affiliations

¹ School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK.
² Centre of New Technologies, University of Warsaw, Banacha 2C, 02089, Warszawa, Poland.
³ Institute for Spectroscopy, Russian Academy of Sciences, Fizicheskaya 5, 142190, Moscow, Troitsk, Russia.
⁴ Mestrelab Research S.L., Feliciano Barrera 9B-Bajo, 15706, Santiago de Compostela, Spain.
⁵ School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK. Craig.Butts@bris.ac.uk.

PMID: 27412569
DOI: 10.1002/cphc.201600541

Abstract

A strong case exists for the introduction of burst non-uniform sampling (NUS) in the direct dimension of NMR spectroscopy experiments. The resulting gaps in the NMR free induction decay can reduce the power demands of long experiments (by switching off broadband decoupling for example) and/or be used to introduce additional pulses (to refocus homonuclear coupling, for example). The final EXtended ACquisition Time (EXACT) spectra are accessed by algorithmic reconstruction of the missing data points and can provide higher resolution in the direct dimension than is achievable with existing non-NUS methods.

Keywords: NMR spectroscopy; algorithmic reconstruction; data sampling sampling.