[Rapamycin opens the era of targeted molecular therapy of venous malformations]

MeSH terms

• Animals
• Disease Models, Animal
• Human Umbilical Vein Endothelial Cells
• Humans
• Mice
• Molecular Targeted Therapy / methods
• Molecular Targeted Therapy / trends*
• Phosphatidylinositol 3-Kinases / metabolism
• Proto-Oncogene Proteins c-akt / metabolism
• Receptor, TIE-2 / antagonists & inhibitors
• Receptor, TIE-2 / physiology
• Signal Transduction
• Sirolimus / therapeutic use*
• TOR Serine-Threonine Kinases / metabolism
• Vascular Diseases / therapy*
• Vascular Malformations / therapy*